| First Author | Chandran S | Year | 2020 |
| Journal | Front Immunol | Volume | 11 |
| Pages | 787 | PubMed ID | 32431707 |
| Mgi Jnum | J:308207 | Mgi Id | MGI:6714522 |
| Doi | 10.3389/fimmu.2020.00787 | Citation | Chandran S, et al. (2020) Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization. Front Immunol 11:787 |
| abstractText | Macrophage responses contribute to a diverse array of pathologies ranging from infectious disease to sterile inflammation. Polarization of macrophages determines their cellular function within biological processes. Lipin-1 is a phosphatidic acid phosphatase in which its enzymatic activity contributes to macrophage pro-inflammatory responses. Lipin-1 also possesses transcriptional co-regulator activity and whether this activity is required for macrophage polarization is unknown. Using mice that lack only lipin-1 enzymatic activity or both enzymatic and transcriptional coregulator activities from myeloid cells, we investigated the contribution of lipin-1 transcriptional co-regulator function toward macrophage wound healing polarization. Macrophages lacking both lipin-1 activities did not elicit IL-4 mediated gene expression to levels seen in either wild-type or lipin-1 enzymatically deficient macrophages. Furthermore, mice lacking myeloid-associated lipin-1 have impaired full thickness excisional wound healing compared to wild-type mice or mice only lacking lipin-1 enzymatic activity from myeloid cell. Our study provides evidence that lipin-1 transcriptional co-regulatory activity contributes to macrophage polarization and influences wound healing in vivo. |
