| First Author | Rao DM | Year | 2019 |
| Journal | J Innate Immun | Volume | 11 |
| Issue | 6 | Pages | 469-480 |
| PubMed ID | 30884482 | Mgi Jnum | J:317465 |
| Mgi Id | MGI:6856502 | Doi | 10.1159/000496405 |
| Citation | Rao DM, et al. (2019) Mice Lacking Fatty Acid-Binding Protein 5 Are Resistant to Listeria monocytogenes. J Innate Immun 11(6):469-480 |
| abstractText | To investigate the role of fatty acid-binding protein 5 (FABP5) in infectious diseases, FABP5-deficient mice were challenged with Listeria monocytogenes, a facultative intracellular bacterial pathogen. Interestingly, FABP5-deficient animals were able to clear the infection within 3 days whereas control wild-type (WT) animals showed comparatively higher bacterial burdens in the liver and spleen. Sections of infected tissues showed an increase in inflammatory foci in WT mice compared to FABP5-deficient mice. FABP5-deficient mice had lower circulating inflammatory cytokines and increased inducible nitric oxide synthase production. FABP5-deficient mouse bone marrow-derived macrophages produced higher levels of nitrite anion than their WT counterparts in response to various stimuli. Additionally, in contrast to FABP5-/- mice, transgenic mice overexpressing FABP5 in myeloid cells (LysM-Cre driven) showed decreased survival rates and increased bacterial burden and inflammatory cytokines. Overall, these findings suggest that increased FABP5 levels correlate with a higher L. monocytogenes bacterial burden and elevated subsequent inflammation. |
