| First Author | Wiedemann SJ | Year | 2022 |
| Journal | Cell Metab | Volume | 34 |
| Issue | 7 | Pages | 991-1003.e6 |
| PubMed ID | 35750050 | Mgi Jnum | J:326748 |
| Mgi Id | MGI:7311467 | Doi | 10.1016/j.cmet.2022.06.001 |
| Citation | Wiedemann SJ, et al. (2022) The cephalic phase of insulin release is modulated by IL-1beta. Cell Metab 34(7):991-1003.e6 |
| abstractText | The initial cephalic phase of insulin secretion is mediated through the vagus nerve and is not due to glycemic stimulation of pancreatic beta cells. Recently, IL-1beta was shown to stimulate postprandial insulin secretion. Here, we describe that this incretin-like effect of IL-1beta involves neuronal transmission. Furthermore, we found that cephalic phase insulin release was mediated by IL-1beta originating from microglia. Moreover, IL-1beta activated the vagus nerve to induce insulin secretion and regulated the activity of the hypothalamus in response to cephalic stimulation. Notably, cephalic phase insulin release was impaired in obesity, in both mice and humans, and in mice, this was due to dysregulated IL-1beta signaling. Our findings attribute a regulatory role to IL-1beta in the integration of nutrient-derived sensory information, subsequent neuronally mediated insulin secretion, and the dysregulation of autonomic cephalic phase responses in obesity. |
