| First Author | Lokken-Toyli KL | Year | 2021 |
| Journal | Mucosal Immunol | Volume | 14 |
| Issue | 6 | Pages | 1358-1368 |
| PubMed ID | 34465896 | Mgi Jnum | J:360404 |
| Mgi Id | MGI:7797582 | Doi | 10.1038/s41385-021-00438-y |
| Citation | Lokken-Toyli KL, et al. (2021) Decreased production of epithelial-derived antimicrobial molecules at mucosal barriers during early life. Mucosal Immunol 14(6):1358-1368 |
| abstractText | Young age is a risk factor for respiratory and gastrointestinal infections. Here, we compared infant and adult mice to identify age-dependent mechanisms that drive susceptibility to mucosal infections during early life. Transcriptional profiling of the upper respiratory tract (URT) epithelium revealed significant dampening of early life innate mucosal defenses. Epithelial-mediated production of the most abundant antimicrobial molecules, lysozyme, and lactoferrin, and the polymeric immunoglobulin receptor (pIgR), responsible for IgA transcytosis, was expressed in an age-dependent manner. This was attributed to delayed functional development of serous cells. Absence of epithelial-derived lysozyme and the pIgR was also observed in the small intestine during early life. Infection of infant mice with lysozyme-susceptible strains of Streptococcus pneumoniae or Staphylococcus aureus in the URT or gastrointestinal tract, respectively, demonstrated an age-dependent regulation of lysozyme enzymatic activity. Lysozyme derived from maternal milk partially compensated for the reduction in URT lysozyme activity of infant mice. Similar to our observations in mice, expression of lysozyme and the pIgR in nasopharyngeal samples collected from healthy human infants during the first year of life followed an age-dependent regulation. Thus, a global pattern of reduced antimicrobial and IgA-mediated defenses may contribute to increased susceptibility of young children to mucosal infections. |
