| First Author | Brines R | Year | 2018 |
| Journal | Oxid Med Cell Longev | Volume | 2018 |
| Pages | 5053091 | PubMed ID | 29599896 |
| Mgi Jnum | J:318475 | Mgi Id | MGI:6859807 |
| Doi | 10.1155/2018/5053091 | Citation | Brines R, et al. (2018) Myeloid Heme Oxygenase-1 Regulates the Acute Inflammatory Response to Zymosan in the Mouse Air Pouch. Oxid Med Cell Longev 2018:5053091 |
| abstractText | Heme oxygenase-1 (HO-1) is induced by many stimuli to modulate the activation and function of different cell types during innate immune responses. Although HO-1 has shown anti-inflammatory effects in different systems, there are few data on the contribution of myeloid HO-1 and its role in inflammatory processes is not well understood. To address this point, we have used HO-1(M-KO) mice with myeloid-restricted deletion of HO-1 to specifically investigate its influence on the acute inflammatory response to zymosan in vivo. In the mouse air pouch model, we have shown an exacerbated inflammation in HO-1(M-KO) mice with increased neutrophil infiltration accompanied by high levels of inflammatory mediators such as interleukin-1beta, tumor necrosis factor-alpha, and prostaglandin E2. The expression of the degradative enzyme matrix metalloproteinase-3 (MMP-3) was also enhanced. In addition, we observed higher levels of serum MMP-3 in HO-1(M-KO) mice compared with control mice, suggesting the presence of systemic inflammation. Altogether, these findings demonstrate that myeloid HO-1 plays an anti-inflammatory role in the acute response to zymosan in vivo and suggest the interest of this target to regulate inflammatory processes. |
