| First Author | Navarro-Pando JM | Year | 2021 |
| Journal | Sci Adv | Volume | 7 |
| Issue | 1 | PubMed ID | 33523841 |
| Mgi Jnum | J:307619 | Mgi Id | MGI:6721227 |
| Doi | 10.1126/sciadv.abc7409 | Citation | Navarro-Pando JM, et al. (2021) Inhibition of the NLRP3 inflammasome prevents ovarian aging. Sci Adv 7(1) |
| abstractText | Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1beta was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-Mullerian hormone levels and autophagy rates in ovaries. Deficiency of NLRP3 also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 using a direct NLRP3 inhibitor, MCC950, improved fertility in female mice to levels comparable to those of Nlrp3(-/-) mice. These results suggest that the NLRP3 inflammasome is implicated in the age-dependent loss of female fertility and position this inflammasome as a potential new therapeutic target for the treatment of infertility. |
