| First Author | Mahabeleshwar GH | Year | 2011 |
| Journal | Immunity | Volume | 34 |
| Issue | 5 | Pages | 715-28 |
| PubMed ID | 21565532 | Mgi Jnum | J:172120 |
| Mgi Id | MGI:5004733 | Doi | 10.1016/j.immuni.2011.04.014 |
| Citation | Mahabeleshwar GH, et al. (2011) The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock. Immunity 34(5):715-28 |
| abstractText | Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vivo. Exposure of myeloid cells to hypoxia and/or bacterial products reduced KLF2 expression while inducing hypoxia inducible factor-1alpha (HIF-1alpha), findings that were recapitulated in human septic patients. Myeloid KLF2 was found to be a potent inhibitor of nuclear factor-kappaB (NF-kappaB)-dependent HIF-1alpha transcription and, consequently, a critical determinant of outcome in models of polymicrobial infection and endotoxemia. Collectively, these observations identify KLF2 as a tonic repressor of myeloid cell activation in vivo and an essential regulator of the innate immune system. |
