| First Author | Vujić Spasić M | Year | 2008 |
| Journal | Cell Metab | Volume | 7 |
| Issue | 2 | Pages | 173-8 |
| PubMed ID | 18249176 | Mgi Jnum | J:132134 |
| Mgi Id | MGI:3775169 | Doi | 10.1016/j.cmet.2007.11.014 |
| Citation | Vujic Spasic M, et al. (2008) Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab 7(2):173-8 |
| abstractText | Hereditary hemochromatosis (HH) is a prevalent, potentially fatal disorder of iron metabolism hallmarked by intestinal hyperabsorption of iron, hyperferremia, and hepatic iron overload. In both humans and mice, type I HH is associated with mutations in the broadly expressed HFE/Hfe gene. To identify where Hfe acts to prevent HH, we generated mice with tissue-specific Hfe ablations. This work demonstrates that local Hfe expression in hepatocytes serves to maintain physiological iron homeostasis, answering a long-standing question in medicine and explaining earlier clinical observations. |
