| First Author | Sorrelle N | Year | 2017 |
| Journal | J Leukoc Biol | Volume | 102 |
| Issue | 2 | Pages | 277-286 |
| PubMed ID | 28356350 | Mgi Jnum | J:252704 |
| Mgi Id | MGI:5926973 | Doi | 10.1189/jlb.3MR1116-475R |
| Citation | Sorrelle N, et al. (2017) From top to bottom: midkine and pleiotrophin as emerging players in immune regulation. J Leukoc Biol 102(2):277-286 |
| abstractText | Cytokines are pivotal in the generation and resolution of the inflammatory response. The midkine/pleiotrophin (MK/PTN) family of cytokines, composed of just two members, was discovered as heparin-binding neurite outgrowth-promoting factors. Since their discovery, expression of this cytokine family has been reported in a wide array of inflammatory diseases and cancer. In this minireview, we will discuss the emerging appreciation of the functions of the MK/PTN family in the immune system, which include promoting lymphocyte survival, sculpting myeloid cell phenotype, driving immune cell chemotaxis, and maintaining hematopoiesis. |
