Other
12 Authors
- Li F,
- Li Y,
- Liu M,
- Deng Q,
- Yan F,
- Conklin DJ,
- Bhatnagar A,
- Lu Z,
- Wang L,
- Ma X,
- Srivastava S,
- McCracken J
| First Author | Ma X | Year | 2015 |
| Journal | Cell Discov | Volume | 1 |
| Pages | 15005 | PubMed ID | 27462406 |
| Mgi Jnum | J:237900 | Mgi Id | MGI:5817367 |
| Doi | 10.1038/celldisc.2015.5 | Citation | Ma X, et al. (2015) Modulation of tumorigenesis by the pro-inflammatory microRNA miR-301a in mouse models of lung cancer and colorectal cancer. Cell Discov 1:15005 |
| abstractText | Lung cancer and colorectal cancer account for over one-third of all cancer deaths in the United States. MicroRNA-301a (miR-301a) is an activator of both nuclear factor-kappaB (NF-kappaB) and Stat3, and is overexpressed in both deadly malignancies. In this work, we show that genetic ablation of miR-301a reduces Kras-driven lung tumorigenesis in mice. And miR-301a deficiency protects animals from dextran sodium sulfate-induced colon inflammation and colitis-associated colon carcinogenesis. We also demonstrate that miR-301a deletion in bone marrow-derived cells attenuates tumor growth in the colon carcinogenesis model. Our findings ascertain that one microRNA-miR-301a-activates two major inflammatory pathways (NF-kappaB and Stat3) in vivo, generating a pro-inflammatory microenvironment that facilitates tumorigenesis. |
