| First Author | Bilkei-Gorzó A | Year | 2008 |
| Journal | Behav Brain Res | Volume | 186 |
| Issue | 2 | Pages | 289-92 |
| PubMed ID | 17904656 | Mgi Jnum | J:148659 |
| Mgi Id | MGI:3846033 | Doi | 10.1016/j.bbr.2007.08.027 |
| Citation | Bilkei-Gorzo A, et al. (2008) Environmental modulation of anxiety-related neuronal activity and behaviors. Behav Brain Res 186(2):289-92 |
| abstractText | Enkephalin-deficient knockout mice, a genetic model of enhanced anxiety responses, and wild-type controls were housed in two separate facilities on the same campus using different caging systems. Stress reactivity was evaluated in these animals using a zero-maze test followed by c-Fos expression analysis in limbic brain regions. Animals with genetically or pharmacologically enhanced anxiety reared and tested in the same facility displayed similar behavioral reactivity and c-Fos induction. However, we found much stronger anxiety-related behavioral responses and higher c-Fos levels when animals were house in individually ventilated cages, independent of their genetic background. |
