| First Author | Valverde O | Year | 2000 |
| Journal | J Neurosci | Volume | 20 |
| Issue | 24 | Pages | 9284-9 |
| PubMed ID | 11125007 | Mgi Jnum | J:66732 |
| Mgi Id | MGI:1929040 | Doi | 10.1523/JNEUROSCI.20-24-09284.2000 |
| Citation | Valverde O, et al. (2000) Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-Out mice. J Neurosci 20(24):9284-9 |
| abstractText | The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol was reduced in mutant mice, whereas no difference between genotypes was observed in the effects induced on body temperature, locomotion, or ring catalepsy. During a chronic treatment with Delta9-tetrahydrocannabinol, the development of tolerance to the analgesic responses induced by this compound was slower in mice lacking enkephalin. In addition, cannabinoid withdrawal syndrome, precipitated in Delta9-tetrahydrocannabinol-dependent mice by the injection of SR141716A, was significantly attenuated in mutant mice. These results indicate that the endogenous enkephalinergic system is involved in the antinociceptive responses of Delta9-tetrahydrocannabinol and participates in the expression of cannabinoid abstinence. |
