| First Author | Okuyama S | Year | 1999 |
| Journal | Neurosci Lett | Volume | 261 |
| Issue | 3 | Pages | 167-70 |
| PubMed ID | 10081975 | Mgi Jnum | J:108033 |
| Mgi Id | MGI:3622874 | Doi | 10.1016/s0304-3940(99)00002-6 |
| Citation | Okuyama S, et al. (1999) Reduction of depressive-like behavior in mice lacking angiotensinogen. Neurosci Lett 261(3):167-70 |
| abstractText | We made use of targeted disruption of the mouse angiotensinogen (ATN) gene to examine the functional role of the ATN in the central nervous system. Both male and female ATN-deficient mice displayed the reduction of depressive-like behavior in the behavioral despair swim tests and spontaneous locomotor activity diminished. However, both male and female ATN-deficient mice showed no anxiogenic-like or memory-deficit behavior and there was no change in the pain threshold. We propose that endogenous ATN in the central nervous system may regulate the depressant state in the brain. |
