| First Author | Chen K | Year | 2021 |
| Journal | Front Cell Dev Biol | Volume | 9 |
| Pages | 721561 | PubMed ID | 35118061 |
| Mgi Jnum | J:326679 | Mgi Id | MGI:6864725 |
| Doi | 10.3389/fcell.2021.721561 | Citation | Chen K, et al. (2021) Osteocytic HIF-1alpha Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation. Front Cell Dev Biol 9:721561 |
| abstractText | The activation of hypoxia-inducible factor 1alpha (HIF-1alpha) signaling has promising implications for the treatment of bone diseases such as osteoporosis and skeletal fractures. However, the effects of manipulating HIF-1alpha pathway on bone micro-structure and remodeling should be fully studied before the clinical application of therapeutics that interfere with the HIF-1alpha pathway. In this study, we found that osteocyte-specific HIF-1alpha pathway had critical role in manipulating bone mass accrual, bone material properties and micro-structures, including bone mineralization, bone collagen fiber formation, osteocyte/canalicular network, and bone remodeling. In addition, our results suggest that osteocyte-specific HIF-1alpha pathway regulates bone micro-structure and remodeling via impairing osteocyte differentiation and maturation. |
