| First Author | Ide S | Year | 2005 |
| Journal | Neurosci Lett | Volume | 386 |
| Issue | 1 | Pages | 14-7 |
| PubMed ID | 15975715 | Mgi Jnum | J:102566 |
| Mgi Id | MGI:3607765 | Doi | 10.1016/j.neulet.2005.05.056 |
| Citation | Ide S, et al. (2005) Defect in normal developmental increase of the brain biogenic amine concentrations in the mecp2-null mouse. Neurosci Lett 386(1):14-7 |
| abstractText | To clarify whether Mecp2 dysfunction may cause impairment of the monoaminergic and serotonergic systems, we measured the whole brain concentrations of biogenic amines and related substrates in three mecp2-null male mice and four control mice of each age at 0-42 postnatal days by HPLC methods. After 14 postnatal days, concentrations of biogenic amines were smaller in mecp2-null mice than those in control mice and at 42 postnatal days, norepinephrine, dopamine and serotonin concentrations in mecp2-null mice were significantly smaller by 25, 24 and 16%, respectively. This result suggested that the absence of Mecp2 does not impair the neurogenesis of monoaminergic and serotonergic neurons but causes succeeding impairment of those neuronal systems from 14 postnatal days. |
