| First Author | Ito-Ishida A | Year | 2018 |
| Journal | Nat Neurosci | Volume | 21 |
| Issue | 6 | Pages | 794-798 |
| PubMed ID | 29802390 | Mgi Jnum | J:264671 |
| Mgi Id | MGI:6196651 | Doi | 10.1038/s41593-018-0155-8 |
| Citation | Ito-Ishida A, et al. (2018) Genome-wide distribution of linker histone H1.0 is independent of MeCP2. Nat Neurosci 21(6):794-798 |
| abstractText | Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar genomic regions and the Flag-H1.0 binding was not changed upon MeCP2 depletion. Furthermore, mild overexpression of H1.0 did not alter MeCP2 binding, suggesting that the functional binding of MeCP2 and H1.0 are largely independent. |
