| First Author | Cariou B | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 19 | Pages | 4076-80 |
| PubMed ID | 16023103 | Mgi Jnum | J:100327 |
| Mgi Id | MGI:3587984 | Doi | 10.1016/j.febslet.2005.06.033 |
| Citation | Cariou B, et al. (2005) Transient impairment of the adaptive response to fasting in FXR-deficient mice. FEBS Lett 579(19):4076-80 |
| abstractText | The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transiently lower in FXR-/- mice after 6h of fasting and was decreased in FXR-/- hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting. |
