| First Author | Safaiyan S | Year | 2016 |
| Journal | Nat Neurosci | Volume | 19 |
| Issue | 8 | Pages | 995-8 |
| PubMed ID | 27294511 | Mgi Jnum | J:238155 |
| Mgi Id | MGI:5818402 | Doi | 10.1038/nn.4325 |
| Citation | Safaiyan S, et al. (2016) Age-related myelin degradation burdens the clearance function of microglia during aging. Nat Neurosci 19(8):995-8 |
| abstractText | Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging. |
