| First Author | Langer HF | Year | 2011 |
| Journal | Cancer Res | Volume | 71 |
| Issue | 12 | Pages | 4096-105 |
| PubMed ID | 21593193 | Mgi Jnum | J:173391 |
| Mgi Id | MGI:5013986 | Doi | 10.1158/0008-5472.CAN-10-2794 |
| Citation | Langer HF, et al. (2011) A Novel Function of Junctional Adhesion Molecule-C in Mediating Melanoma Cell Metastasis. Cancer Res 71(12):4096-4105 |
| abstractText | Hematogenous dissemination of melanoma is a life-threatening complication of this malignant tumor. Here, we identified junctional adhesion molecule-C (JAM-C) as a novel player in melanoma metastasis to the lung. JAM-C expression was identified in human and murine melanoma cell lines, in human malignant melanoma, as well as in metastatic melanoma including melanoma lung metastasis. JAM-C expressed on both murine B16 melanoma cells as well as on endothelial cells promoted the transendothelial migration of the melanoma cells. We generated mice with inactivation of JAM-C. JAM-C(-/-) mice as well as endothelial-specific JAM-C-deficient mice displayed significantly decreased B16 melanoma cell metastasis to the lung, whereas treatment of mice with soluble JAM-C prevented melanoma lung metastasis. Together, JAM-C represents a novel therapeutic target for melanoma metastasis. Cancer Res; 71(12); 4096-105. (c)2011 AACR. |
