| First Author | Sommers CL | Year | 2002 |
| Journal | Science | Volume | 296 |
| Issue | 5575 | Pages | 2040-3 |
| PubMed ID | 12065840 | Mgi Jnum | J:77099 |
| Mgi Id | MGI:2180997 | Doi | 10.1126/science.1069066 |
| Citation | Sommers CL, et al. (2002) A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 296(5575):2040-3 |
| abstractText | Mice homozygous for a single tyrosine mutation in LAT (linker for activation of T cells) exhibited an early block in T cell maturation but later developed a polyclonal lymphoproliferative disorder and signs of autoimmune disease. T cell antigen receptor (TCR)-induced activation of phospholipase C-gamma1 (PLC-gamma1) and of nuclear factor of activated T cells, calcium influx, interleukin-2 production, and cell death were reduced or abrogated in T cells from LAT mutant mice. In contrast, TCR-induced Erk activation was intact. These results identify a critical role for integrated PLC-gamma1 and Ras-Erk signaling through LAT in T cell development and homeostasis. |
