| First Author | Boldin MP | Year | 2011 |
| Journal | J Exp Med | Volume | 208 |
| Issue | 6 | Pages | 1189-201 |
| PubMed ID | 21555486 | Mgi Jnum | J:173671 |
| Mgi Id | MGI:5049875 | Doi | 10.1084/jem.20101823 |
| Citation | Boldin MP, et al. (2011) miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med 208(6):1189-201 |
| abstractText | Excessive or inappropriate activation of the immune system can be deleterious to the organism, warranting multiple molecular mechanisms to control and properly terminate immune responses. MicroRNAs (miRNAs), approximately 22-nt-long noncoding RNAs, have recently emerged as key posttranscriptional regulators, controlling diverse biological processes, including responses to non-self. In this study, we examine the biological role of miR-146a using genetically engineered mice and show that targeted deletion of this gene, whose expression is strongly up-regulated after immune cell maturation and/or activation, results in several immune defects. Collectively, our findings suggest that miR-146a plays a key role as a molecular brake on inflammation, myeloid cell proliferation, and oncogenic transformation. |
