Other
12 Authors
- Anderson CT,
- Gao J,
- Wu X,
- Cheng WH,
- Cheatham MA,
- He DZ,
- Sengupta S,
- Zuo J,
- Jia S,
- Zheng J,
- Wang X,
- Dallos P
| First Author | Dallos P | Year | 2008 |
| Journal | Neuron | Volume | 58 |
| Issue | 3 | Pages | 333-9 |
| PubMed ID | 18466744 | Mgi Jnum | J:145297 |
| Mgi Id | MGI:3834282 | Doi | 10.1016/j.neuron.2008.02.028 |
| Citation | Dallos P, et al. (2008) Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron 58(3):333-9 |
| abstractText | It is a central tenet of cochlear neurobiology that mammalian ears rely on a local, mechanical amplification process for their high sensitivity and sharp frequency selectivity. While it is generally agreed that outer hair cells provide the amplification, two mechanisms have been proposed: stereociliary motility and somatic motility. The latter is driven by the motor protein prestin. Electrophysiological phenotyping of a prestin knockout mouse intimated that somatic motility is the amplifier. However, outer hair cells of knockout mice have significantly altered mechanical properties, making this mouse model unsatisfactory. Here, we study a mouse model without alteration to outer hair cell and organ of Corti mechanics or to mechanoelectric transduction, but with diminished prestin function. These animals have knockout-like behavior, demonstrating that prestin-based electromotility is required for cochlear amplification. |
