| First Author | Chakravarthy MV | Year | 2008 |
| Journal | Diabetes | Volume | 57 |
| Issue | 10 | Pages | 2698-707 |
| PubMed ID | 18591393 | Mgi Jnum | J:141896 |
| Mgi Id | MGI:3820002 | Doi | 10.2337/db08-0404 |
| Citation | Chakravarthy MV, et al. (2008) Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age. Diabetes 57(10):2698-707 |
| abstractText | OBJECTIVE: Low birth weight is associated with diabetes in adult life. Accelerated or 'catch-up' postnatal growth in response to small birth size is thought to presage disease years later. Whether adult disease is caused by intrauterine beta-cell-specific programming or by altered metabolism associated with catch-up growth is unknown. RESEARCH DESIGN AND METHODS: We generated a new model of intrauterine growth restriction due to fatty acid synthase (FAS) haploinsufficiency (FAS deletion [FASDEL]). Developmental programming of diabetes in these mice was assessed from in utero to 1 year of age. RESULTS: FASDEL mice did not manifest catch-up growth or insulin resistance. beta-Cell mass and insulin secretion were strikingly increased in young FASDEL mice, but beta-cell failure and diabetes occurred with age. FASDEL beta-cells had altered proliferative and apoptotic responses to the common stress of a high-fat diet. This sequence appeared to be developmentally entrained because beta-cell mass was increased in utero in FASDEL mice and in another model of intrauterine growth restriction caused by ectopic expression of uncoupling protein-1. Increasing intrauterine growth in FASDEL mice by supplementing caloric intake of pregnant dams normalized beta-cell mass in utero. CONCLUSIONS: Decreased intrauterine body size, independent of postnatal growth and insulin resistance, appears to regulate beta-cell mass, suggesting that developing body size might represent a physiological signal that is integrated through the pancreatic beta-cell to establish a template for hyperfunction in early life and beta-cell failure with age. |
