| First Author | Bogenmann E | Year | 2011 |
| Journal | Genesis | Volume | 49 |
| Issue | 11 | Pages | 862-9 |
| PubMed ID | 21413144 | Mgi Jnum | J:178666 |
| Mgi Id | MGI:5299419 | Doi | 10.1002/dvg.20747 |
| Citation | Bogenmann E, et al. (2011) Generation of mice with a conditional allele for the p75(NTR) neurotrophin receptor gene. Genesis 49(11):862-9 |
| abstractText | The p75(NTR) neurotrophin receptor has been implicated in multiple biological and pathological processes. While significant advances have recently been made in understanding the physiologic role of p75(NTR) , many details and aspects remain to be determined. This is in part because the two existing knockout mouse models (Exons 3 or 4 deleted, respectively), both display features that defy definitive conclusions. Here we describe the generation of mice that carry a conditional p75(NTR) (p75(NTR-FX) ) allele made by flanking Exons 4-6, which encode the transmembrane and all cytoplasmic domains, by loxP sites. To validate this novel conditional allele, both neural crest-specific p75(NTR) /Wnt1-Cre mutants and conventional p75(NTR) null mutants were generated. Both mutants displayed abnormal hind limb reflexes, implying that loss of p75(NTR) in neural crest-derived cells causes a peripheral neuropathy similar to that seen in conventional p75(NTR) mutants. This novel conditional p75(NTR) allele will offer new opportunities to investigate the role of p75(NTR) in specific tissues and cells. |
