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Allele : Tnf<tm1Gkl> tumor necrosis factor; targeted mutation 1, George Kollias

Primary Identifier  MGI:2149024 Allele Type  Targeted
Attribute String  Null/knockout Gene  Tnf
Transmission  Germline Strain of Origin  129S/SvEv-Gpi1<c>
Is Recombinase  false Is Wild Type  false
molecularNote  Replacement of 40 bp of the 5' UTR, all the coding region, including the ATG translation initiation codon, of the first exon and part of the first intron with MC1neopA cassette. Northern blot analysis of LPS stimulated macrophages confirmed disruption of Tnf mRNA expression.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • TNFalpha KO,
  • TNFalpha KO,
  • Tnf-alpha-,
  • Tnf0,
  • Tnf-alpha-,
  • TNFalpha<->,
  • Tnf0,
  • TNFKO,
  • TNFalpha<->,
  • TNFalpha<->,
  • TNF-,
  • TNF-,
  • TNFKO
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

9 Carried By

Trail: Allele

0 Driven By

501 Publication categories

Trail: Allele