| First Author | Jiang Q | Year | 2017 |
| Journal | Cell Death Dis | Volume | 8 |
| Issue | 10 | Pages | e3146 |
| PubMed ID | 29072682 | Mgi Jnum | J:329704 |
| Mgi Id | MGI:6831878 | Doi | 10.1038/cddis.2017.560 |
| Citation | Jiang Q, et al. (2017) C-X-C motif chemokine ligand 10 produced by mouse Sertoli cells in response to mumps virus infection induces male germ cell apoptosis. Cell Death Dis 8(10):e3146 |
| abstractText | Mumps virus (MuV) infection usually results in germ cell degeneration in the testis, which is an etiological factor for male infertility. However, the mechanisms by which MuV infection damages male germ cells remain unclear. The present study showed that C-X-C motif chemokine ligand 10 (CXCL10) is produced by mouse Sertoli cells in response to MuV infection, which induces germ cell apoptosis through the activation of caspase-3. CXC chemokine receptor 3 (CXCR3), a functional receptor of CXCL10, is constitutively expressed in male germ cells. Neutralizing antibodies against CXCR3 and an inhibitor of caspase-3 activation significantly inhibited CXCL10-induced male germ cell apoptosis. Furthermore, the tumor necrosis factor-alpha (TNF-alpha) upregulated CXCL10 production in Sertoli cells after MuV infection. The knockout of either CXCL10 or TNF-alpha reduced germ cell apoptosis in the co-cultures of germ cells and Sertoli cells in response to MuV infection. Local injection of MuV into the testes of mice confirmed the involvement of CXCL10 in germ cell apoptosis in vivo. These results provide novel insights into MuV-induced germ cell apoptosis in the testis. |
