| First Author | Valeri V | Year | 2021 |
| Journal | Eur J Immunol | Volume | 51 |
| Issue | 2 | Pages | 445-458 |
| PubMed ID | 32920851 | Mgi Jnum | J:302284 |
| Mgi Id | MGI:6506949 | Doi | 10.1002/eji.202048668 |
| Citation | Valeri V, et al. (2021) Mast cells crosstalk with B cells in the gut and sustain IgA response in the inflamed intestine. Eur J Immunol 51(2):445-458 |
| abstractText | B lymphocytes are among the cell types whose effector functions are modulated by mast cells (MCs). The B/MC crosstalk emerged in several pathological settings, notably the colon of inflammatory bowel disease (IBD) patients is a privileged site in which MCs and IgA(+) cells physically interact. Herein, by inducing conditional depletion of MCs in red MC and basophil (RMB) mice, we show that MCs control B cell distribution in the gut and IgA serum levels. Moreover, in dextran sulfate sodium (DSS)-treated RMB mice, the presence of MCs is fundamental for the enlargement of the IgA(+) population in the bowel and the increase of systemic IgA production. Since both conventional B-2 and peritoneal-derived B cells populate the intestine and communicate with MCs in physiological conditions and during inflammation, we further explored this interplay through the use of co-cultures. We show that MCs finely regulate different aspects of splenic B cell biology while peritoneal B cells are unresponsive to the supporting effects provided by MCs. Interestingly, peritoneal B cells induce a pro-inflammatory skewing in MCs, characterized by increased ST2 and TNF-alpha expression. Altogether, this study uncovers the versatility of the B/MC liaison and highlights key aspects for the resolution of intestinal inflammation. |
