| First Author | Kassiotis G | Year | 2001 |
| Journal | J Neuroimmunol | Volume | 119 |
| Issue | 2 | Pages | 239-47 |
| PubMed ID | 11585627 | Mgi Jnum | J:103105 |
| Mgi Id | MGI:3608463 | Doi | 10.1016/s0165-5728(01)00403-9 |
| Citation | Kassiotis G, et al. (2001) Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness. J Neuroimmunol 119(2):239-47 |
| abstractText | We report here that tumor necrosis factor (TNF) deficiency causes innate hypo-responsiveness to a broad range of bacterial or viral constituents. In vivo hypo-responsiveness of TNF-deficient mice to mycobacteria results in defective CD4+ T cell priming to antigens administered in complete Freund's adjuvant (CFA). This deficiency is restored by supplementary mycobacteria. Furthermore, we show that even when self-reactive CD4+ T cell priming is fully restored, susceptibility of TNF-deficient mice to experimental autoimmune encephalomyelitis (EAE) depends on the co-administered pertussis toxin (PTx). TNF-deficient mice are completely resistant to EAE at sub-optimal doses of PTx, while supplementary PTx restores susceptibility. Therefore, TNF shows distinct functions in linking innate responsiveness to CD4+ T cell priming and to the induction of autoimmune disease. |
