| Primary Identifier | MGI:2150346 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Fgf8 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd-Hprt1<b-m3> |
| Is Recombinase | false | Is Wild Type | false |
| description | One of three alleles produced using a targeting construct capable of inducing different allelic variants when mated to mice that express cre, flp, or both. Referred to in the literature as Fgf8delta2,3n, this allele lacks exons 2 and 3 and is a presumed null. Heterozygotes are normal. Homozygotes are smaller than littermates and lack all embryonic mesoderm- derived structures including heart and somites. This mutation causes lethality by embryonic day 10.5 (J:45909). |
| molecularNote | This allele is a derivative of Fgf8tm1.1Mrt in which mice carrying this allele were mated to beta-actin cre mice, which resulted in heterozygous offspring carrying a recombined Fgf8 allele in which exons 2 and 3 were deleted. |
