| First Author | Quinn CE | Year | 2007 |
| Journal | Fertil Steril | Volume | 88 |
| Issue | 4 Suppl | Pages | 1021-8 |
| PubMed ID | 17313947 | Mgi Jnum | J:129604 |
| Mgi Id | MGI:3769839 | Doi | 10.1016/j.fertnstert.2006.11.157 |
| Citation | Quinn CE, et al. (2007) Pinopodes are present in Lif null and Hoxa10 null mice. Fertil Steril 88(4 Suppl):1021-8 |
| abstractText | OBJECTIVE: To assess pinopode formation in Lif null and Hoxa10 null mice with infertility secondary to failed implantation. DESIGN: Controlled animal experiment. SETTING: Animal research and laboratory facility. ANIMAL(S): Lif null, Hoxa10 null, and ICR mice and Sprague-Dawley rats. INTERVENTION(S): Endometrial tissue was collected during the peri-implantation period and after ovariectomy. MAIN OUTCOME MEASURE(S): Endometrial epithelial tissue was examined under scanning-electron microscopy and assigned a score depending on the number of pinopodes present. RESULT(S): Pinopode scores in ICR, Lif null, and Hoxa10 null mice were comparable throughout the peri-implantation period, rising on day 3.5 of pregnancy and remaining elevated through to day 7.5, suggesting that pinopodes are not a good indicator of receptivity in mice. In contrast, pinopode scores in rats clearly demarcated the window of receptivity, appearing on day 4 of pregnancy and declining sharply on day 6. Pinopode scores were low in E(2)-treated ovariectomized mice, but unexpectedly, pinopode scores in vehicle-injected ovariectomized ICR mice were markedly elevated. CONCLUSION(S): Lif null and Hoxa10 null mice, in which implantation is impaired, have a similar number of pinopodes to fertile ICR mice. Pinopodes do not define a window of implantation in mice. |
