| First Author | Yao MW | Year | 2003 |
| Journal | Mol Endocrinol | Volume | 17 |
| Issue | 4 | Pages | 610-27 |
| PubMed ID | 12554760 | Mgi Jnum | J:82683 |
| Mgi Id | MGI:2654387 | Doi | 10.1210/me.2002-0290 |
| Citation | Yao MW, et al. (2003) Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of hoxa-10 in the preimplantation uterus. Mol Endocrinol 17(4):610-27 |
| abstractText | Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterine stromal cells. Hoxa-10 mutants express a stromal cell proliferation defect that is accompanied by quantitative or spatial alterations in the expression of two cyclin-dependent kinase inhibitor genes, p57 and p15. Hoxa-10 deficiencyFS also leads to a severe local immunological disturbance, characterized by a polyclonal proliferation of T cells, that occurs in place of the normal progesterone-mediated immunosuppression in the periimplantation uterus. |
