| First Author | Mikhak Z | Year | 2013 |
| Journal | J Exp Med | Volume | 210 |
| Issue | 9 | Pages | 1855-69 |
| PubMed ID | 23960189 | Mgi Jnum | J:202485 |
| Mgi Id | MGI:5519174 | Doi | 10.1084/jem.20130091 |
| Citation | Mikhak Z, et al. (2013) Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4. J Exp Med 210(9):1855-69 |
| abstractText | T cell trafficking into the lung is critical for lung immunity, but the mechanisms that mediate T cell lung homing are not well understood. Here, we show that lung dendritic cells (DCs) imprint T cell lung homing, as lung DC-activated T cells traffic more efficiently into the lung in response to inhaled antigen and at homeostasis compared with T cells activated by DCs from other tissues. Consequently, lung DC-imprinted T cells protect against influenza more effectively than do gut and skin DC-imprinted T cells. Lung DCs imprint the expression of CCR4 on T cells, and CCR4 contributes to T cell lung imprinting. Lung DC-activated, CCR4-deficient T cells fail to traffic into the lung as efficiently and to protect against influenza as effectively as lung DC-activated, CCR4-sufficient T cells. Thus, lung DCs imprint T cell lung homing and promote lung immunity in part through CCR4. |
