| First Author | Woyciechowski S | Year | 2017 |
| Journal | Eur J Immunol | Volume | 47 |
| Issue | 2 | Pages | 244-250 |
| PubMed ID | 27861803 | Mgi Jnum | J:246412 |
| Mgi Id | MGI:5922440 | Doi | 10.1002/eji.201646722 |
| Citation | Woyciechowski S, et al. (2017) alpha4 beta1 integrin promotes accumulation of tissue-resident memory CD8+ T cells in salivary glands. Eur J Immunol 47(2):244-250 |
| abstractText | The salivary glands (SGs) of virus-immune mice contain substantial numbers of tissue-resident memory CD8+ T cells (TRM cells) that can provide immunity to local infections. Integrins regulate entry of activated T cells into nonlymphoid tissues but the molecules that mediate migration of virus-specific CD8+ T cells to the SGs have not yet been defined. Here, we found that polyinosinic-polycytidylic acid (poly(I:C)) strongly promoted the accumulation of P14 TCR-transgenic CD8+ TRM cells in SGs in an alpha4 beta1 integrin-dependent manner. After infection with lymphocytic choriomeningitis virus, accumulation of P14 TRM cells in SGs and intestine but not in kidney was also alpha4 integrin dependent. Blockade of alpha4 beta7 by monoclonal antibodies (mAbs) inhibited lymphocytic choriomeningitis virus-induced accumulation of P14 TRM cells in the intestine but not in SGs. In conclusion, our data reveal that alpha4 beta1 integrin mediates CD8+ TRM accumulation in SGs and that poly(I:C) can be used to direct activated CD8+ T cells to this organ. |
