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Allele : Ret<tm2Cos> ret proto-oncogene; targeted mutation 2, Frank Costantini

Primary Identifier  MGI:2136895 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Ret
Transmission  Germline Strain of Origin  129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A T to C transition in codon 919, the equivalent codon to human 918, resulted in a protein which encoded threonine instead of methionine at this position (M919T). Silent mutations in codons 920 and 921 abolished a MunI endonuclease site. A loxP flanked neomycin cassette was inserted into an adjacent intron.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • ret<MEN2B-neo>,
  • ret<MEN2B-neo>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories

Trail: Allele