| First Author | Chabrol FP | Year | 2019 |
| Journal | Neuron | Volume | 103 |
| Issue | 3 | Pages | 506-519.e4 |
| PubMed ID | 31201123 | Mgi Jnum | J:279572 |
| Mgi Id | MGI:6355669 | Doi | 10.1016/j.neuron.2019.05.022 |
| Citation | Chabrol FP, et al. (2019) Cerebellar Contribution to Preparatory Activity in Motor Neocortex. Neuron 103(3):506-519.e4 |
| abstractText | In motor neocortex, preparatory activity predictive of specific movements is maintained by a positive feedback loop with the thalamus. Motor thalamus receives excitatory input from the cerebellum, which learns to generate predictive signals for motor control. The contribution of this pathway to neocortical preparatory signals remains poorly understood. Here, we show that, in a virtual reality conditioning task, cerebellar output neurons in the dentate nucleus exhibit preparatory activity similar to that in anterolateral motor cortex prior to reward acquisition. Silencing activity in dentate nucleus by photoactivating inhibitory Purkinje cells in the cerebellar cortex caused robust, short-latency suppression of preparatory activity in anterolateral motor cortex. Our results suggest that preparatory activity is controlled by a learned decrease of Purkinje cell firing in advance of reward under supervision of climbing fiber inputs signaling reward delivery. Thus, cerebellar computations exert a powerful influence on preparatory activity in motor neocortex. |
