| First Author | Lefort JM | Year | 2019 |
| Journal | Nat Commun | Volume | 10 |
| Issue | 1 | Pages | 2251 |
| PubMed ID | 31113954 | Mgi Jnum | J:278506 |
| Mgi Id | MGI:6323746 | Doi | 10.1038/s41467-019-09958-5 |
| Citation | Lefort JM, et al. (2019) Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation. Nat Commun 10(1):2251 |
| abstractText | Cerebellar activity supported by PKC-dependent long-term depression in Purkinje cells (PCs) is involved in the stabilization of self-motion based hippocampal representation, but the existence of cerebellar processes underlying integration of allocentric cues remains unclear. Using mutant-mice lacking PP2B in PCs (L7-PP2B mice) we here assess the role of PP2B-dependent PC potentiation in hippocampal representation and spatial navigation. L7-PP2B mice display higher susceptibility to spatial map instability relative to the allocentric cue and impaired allocentric as well as self-motion goal-directed navigation. These results indicate that PP2B-dependent potentiation in PCs contributes to maintain a stable hippocampal representation of a familiar environment in an allocentric reference frame as well as to support optimal trajectory toward a goal during navigation. |
