Primary Identifier | MGI:2137525 | Allele Type | Targeted |
Attribute String | Null/knockout, Reporter | Gene | Gja8 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A lacZ gene, followed by a neomycin selection cassette, was inserted in-frame after the sixth codon. Western blot analysis demonstrated that no GJA8 protein is detectable in lens homogenates derived from homozygous mice. Beta-galactosidase is expressed from this allele under the control of the endogenous promoter. |