| First Author | Suzuki C | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 14 | Pages | 2357-62 |
| PubMed ID | 21693121 | Mgi Jnum | J:174207 |
| Mgi Id | MGI:5052203 | Doi | 10.1016/j.febslet.2011.06.004 |
| Citation | Suzuki C, et al. (2011) Central PGE(2) exhibits anxiolytic-like activity via EP(1) and EP(4) receptors in a manner dependent on serotonin 5-HT(1A), dopamine D(1) and GABA(A) receptors. FEBS Lett 585(14):2357-62 |
| abstractText | We found that centrally administered prostaglandin (PG) E(2) exhibited anxiolytic-like activity in the elevated plus-maze and open field test in mice. Agonists selective for EP(1) and EP(4) receptors, among four receptor subtypes for PGE(2), mimicked the anxiolytic-like activity of PGE(2). The anxiolytic-like activity of PGE(2) was blocked by an EP(1) or EP(4) antagonist, as well as in EP(4) but not EP(1) knockout mice. Central activation of either EP(1) or EP(4) receptors resulted in anxiolytic-like activity. The PGE(2)-induced anxiolytic-like activity was inhibited by antagonists for serotonin 5-HT(1A), dopamine D(1) and GABA(A) receptors. Taken together, PGE(2) exhibits anxiolytic-like activity via EP(1) and EP(4) receptors, with downstream involvement of 5-HT(1A), D(1) and GABA(A) receptor systems. |
