| First Author | Gonzalez-Billault C | Year | 2001 |
| Journal | Mol Biol Cell | Volume | 12 |
| Issue | 7 | Pages | 2087-98 |
| PubMed ID | 11452005 | Mgi Jnum | J:126993 |
| Mgi Id | MGI:3762462 | Doi | 10.1091/mbc.12.7.2087 |
| Citation | Gonzalez-Billault C, et al. (2001) Evidence for the role of MAP1B in axon formation. Mol Biol Cell 12(7):2087-98 |
| abstractText | Cultured neurons obtained from a hypomorphous MAP1B mutant mouse line display a selective and significant inhibition of axon formation that reflects a delay in axon outgrowth and a reduced rate of elongation. This phenomenon is paralleled by decreased microtubule formation and dynamics, which is dramatic at the distal axonal segment, as well as in growth cones, where the more recently assembled microtubule polymer normally predominates. These neurons also have aberrant growth cone formation and increased actin-based protrusive activity. Taken together, this study provides direct evidence showing that by promoting microtubule dynamics and regulating cytoskeletal organization MAP1B has a crucial role in axon formation. |
