Primary Identifier | MGI:2149414 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Pik3r1 |
Transmission | Germline | Strain of Origin | (C57BL/6NCrlj x CBA/JNCrlj)F1 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A neomycin cassette replaced the first exon, exon 1A, of the gene. Functional analysis showed that deletion of this exon, which contains the initiation codon, abolished expression of the p85a variant, while not disrupting expression of the p50a or p55a splicing variants. |