| First Author | Suzuki H | Year | 1999 |
| Journal | Science | Volume | 283 |
| Issue | 5400 | Pages | 390-2 |
| PubMed ID | 9888854 | Mgi Jnum | J:52228 |
| Mgi Id | MGI:1328661 | Doi | 10.1126/science.283.5400.390 |
| Citation | Suzuki H, et al. (1999) Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phospho- inositide 3-kinase. Science 283(5400):390-2 |
| abstractText | Mice with a targeted gene disruption of p85alpha, a regulatory subunit of phosphoinositide 3-kinase, had impaired B cell development at the pro-B cell stage, reduced numbers of mature B cells and peritoneal CD5+ Ly-1 B cells, reduced B cell proliferative responses, and no T cell-independent antibody production. These phenotypes are nearly identical to those of Btk-/- or xid (X-linked immunodeficiency) mice. These results provide evidence that p85alpha is functionally linked to the Btk pathway in antigen receptor-mediated signal transduction and is pivotal in B cell development and functions. |
