| First Author | Kurebayashi Y | Year | 2016 |
| Journal | Biochem Biophys Res Commun | Volume | 480 |
| Issue | 1 | Pages | 114-119 |
| PubMed ID | 27697523 | Mgi Jnum | J:240558 |
| Mgi Id | MGI:5887162 | Doi | 10.1016/j.bbrc.2016.09.153 |
| Citation | Kurebayashi Y, et al. (2016) TGF-beta-induced phosphorylation of Akt and Foxo transcription factors negatively regulates induced regulatory T cell differentiation. Biochem Biophys Res Commun 480(1):114-119 |
| abstractText | Transforming growth factor-beta (TGF-beta) is a pivotal cytokine in the differentiation of regulatory T cells, and Foxo transcription factors positively regulate this process. On the other hand, the function of Foxo transcription factors is negatively regulated by PI3K/Akt signaling, which is activated by TGF-beta in many types of cells; yet the role of TGF-beta in Akt activity and its downstream substrates in CD4+ T cells, including Foxo transcription factors, remains to be determined. Herein, we demonstrate that TGF-beta selectively induces Akt phosphorylation at Ser473 but not at Thr308 in a class IA PI3K-dependent manner in CD4+ T cells, resulting in the phosphorylation and inhibition of Foxo transcription factors and negatively regulating the differentiation of induced regulatory T cells (iTregs). These observations reveal a novel negative regulatory mechanism involving Akt and Foxo transcription factors induced by TGF-beta in the iTreg differentiation process. |
