| First Author | Nisoli E | Year | 2003 |
| Journal | Science | Volume | 299 |
| Issue | 5608 | Pages | 896-9 |
| PubMed ID | 12574632 | Mgi Jnum | J:81677 |
| Mgi Id | MGI:2449825 | Doi | 10.1126/science.1079368 |
| Citation | Nisoli E, et al. (2003) Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 299(5608):896-9 |
| abstractText | Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric oxide was dependent on guanosine 3',5'-monophosphate (cGMP) and was mediated by the induction of peroxisome proliferator-activated receptor gamma coactivator 1alpha, a master regulator of mitochondrial biogenesis. Moreover, the mitochondrial biogenesis induced by exposure to cold was markedly reduced in brown adipose tissue of endothelial nitric oxide synthase null-mutant (eNOS-/-) mice, which had a reduced metabolic rate and accelerated weight gain as compared to wild-type mice. Thus, a nitric oxide-cGMP-dependent pathway controls mitochondrial biogenesis and body energy balance. |
