| First Author | Agmo A | Year | 2008 |
| Journal | Genes Brain Behav | Volume | 7 |
| Issue | 1 | Pages | 70-7 |
| PubMed ID | 17504245 | Mgi Jnum | J:145605 |
| Mgi Id | MGI:3835277 | Doi | 10.1111/j.1601-183X.2007.00327.x |
| Citation | Agmo A, et al. (2008) Social and sexual incentive properties of estrogen receptor alpha, estrogen receptor beta, or oxytocin knockout mice. Genes Brain Behav 7(1):70-7 |
| abstractText | Social and sexual incentive motivation, defined as the intensity of approach to a social and a sexual incentive, respectively, were studied in female Swiss Webster mice. In the first experiment, the social incentive was a castrated mouse of the same strain as the females, whereas the sexual incentive was an intact male mouse of the same strain. Ovariectomized females were first tested after oil treatment and then after administration of estradiol benzoate + progesterone in doses sufficient to induce full receptivity. The hormones increased sexual incentive motivation while leaving social incentive motivation unaffected. This suggests that sexual incentive motivation in the female mouse is dependent on ovarian hormones. In the next experiment, ovariectomized females were tested with an intact, male estrogen receptor alpha knockout and its wild type as incentives, first without hormones and then when fully receptive. There were no differences in incentive properties between the wild type and the knockout. In a similar experiment, we used an intact male estrogen receptor beta knockout and its corresponding wild type as incentives. The wild type turned out to be a more attractive social incentive than the knockout, while they were equivalent as sexual incentives. Finally, an intact male oxytocin knockout and its wild type were used as incentives. The knockout turned out to be a superior incentive, particularly a superior sexual incentive. The fact that the estrogen receptor beta and oxytocin knockouts have incentive properties different from their wild types may be important to consider in studies of these knockouts' sociosexual behaviors. |
