| First Author | Tomihara K | Year | 2006 |
| Journal | Neuroreport | Volume | 17 |
| Issue | 11 | Pages | 1169-73 |
| PubMed ID | 16837848 | Mgi Jnum | J:111819 |
| Mgi Id | MGI:3654885 | Doi | 10.1097/01.wnr.0000224771.82151.77 |
| Citation | Tomihara K, et al. (2006) Abolition of sex-dependent effects of prenatal exposure to diethylstilbestrol on emotional behavior in estrogen receptor-alpha knockout mice. Neuroreport 17(11):1169-73 |
| abstractText | To investigate the contribution of estrogen receptor-alpha in the effects of prenatal exposure to diethylstilbestrol on emotionality, estrogen receptor-alpha knockout heterozygous pregnant mice were orally given 0.1 microg/animal of diethylstilbestrol from gestational day 11 to 17. Emotional behavior of the offspring was assessed at 5 weeks in light-dark transition tests. Time spent in the light area was significantly decreased (i.e. decrease of emotionality) by diethylstilbestrol exposure in wild-type female mice, whereas in wild-type male mice this measurement tended to be increased (i.e. increase of emotionality) by diethylstilbestrol treatment. These sex-dependent effects of diethylstilbestrol were completely abolished in estrogen receptor-alpha knockout mice. These results suggest that the sex-dependent effects of diethylstilbestrol on emotionality are mainly produced by its action on estrogen receptor-alpha. |
