| First Author | Hwang CJ | Year | 2015 |
| Journal | Mol Neurobiol | Volume | 52 |
| Issue | 1 | Pages | 176-86 |
| PubMed ID | 25128029 | Mgi Jnum | J:310463 |
| Mgi Id | MGI:6762866 | Doi | 10.1007/s12035-014-8853-z |
| Citation | Hwang CJ, et al. (2015) Memory Impairment in Estrogen Receptor alpha Knockout Mice Through Accumulation of Amyloid-beta Peptides. Mol Neurobiol 52(1):176-86 |
| abstractText | Estrogen has been known to reduce the development of Alzheimer's disease (AD). However, exact mechanisms are not clear. We investigated whether estrogen can increase amyloid-beta (Abeta) degradation and affects Abeta-induced memory impairment in an estrogen deficiency model. Estrogen receptor alpha (ERalpha) knockout mice and wild-type mice were intracerebroventricular (ICV) infused with Abeta (300 pmol) for 2 weeks. Cognitive function was then assessed by the Morris water maze test and passive avoidance test. In addition, Western blot analysis, immunostaining, immunofluorescence staining, ELISA, and enzyme activity assays were used to examine the degree of Abeta deposition in the brains of ERalpha knockout mice. In our present study, Abeta was accumulated more in the ERalpha knockout mice brain and greatly worsened memory impairment and glial activation as well as neurogenic inflammation. These results suggest that estrogen may protect memory impairment by stimulating the degradation of Abeta and down-regulate neurogenic inflammation as well as amyloidogenesis. |
