| First Author | Bjursten M | Year | 2004 |
| Journal | Cell Immunol | Volume | 228 |
| Issue | 2 | Pages | 77-80 |
| PubMed ID | 15219458 | Mgi Jnum | J:91100 |
| Mgi Id | MGI:3045934 | Doi | 10.1016/j.cellimm.2004.05.001 |
| Citation | Bjursten M, et al. (2004) Enhanced pro-inflammatory cytokine production in Galphai2-deficient mice on colitis prone and colitis resistant 129Sv genetic backgrounds. Cell Immunol 228(2):77-80 |
| abstractText | Mice deficient in G-protein subunit alphai2 develop colitis closely resembling human ulcerative colitis when raised on 129SvEv background. When backcrossing the Galphai2-deficiency into a 129SvJBom genetic background, surprisingly, mice did not develop colitis. In vitro stimulation of splenocytes with formalin-killed Staphylococcus aureus resulted in significantly increased production of interleukin-1beta, tumor necrosis factor, and interleukin-12p40 in Galphai2(-/-) as compared to control mice. The enhanced production of pro-inflammatory cytokines was seen in colitis prone as well as in colitis resistant genetic background. A similar outcome was seen upon stimulation with toxic shock syndrome toxin-1, a T cell superantigen, except that Galphai2(-/-) colitis resistant 129SvJBom splenocytes did not show increased production of IL-12p40 as compared to their controls. |
