| First Author | Hao W | Year | 2002 |
| Journal | Nat Genet | Volume | 32 |
| Issue | 2 | Pages | 254-60 |
| PubMed ID | 12219089 | Mgi Jnum | J:79561 |
| Mgi Id | MGI:2388495 | Doi | 10.1038/ng984 |
| Citation | Hao W, et al. (2002) Evidence for two apoptotic pathways in light-induced retinal degeneration. Nat Genet 32(2):254-60 |
| abstractText | Excessive phototransduction signaling is thought to be involved in light-induced and inherited retinal degeneration. Using knockout mice with defects in rhodopsin shut-off and transducin signaling, we show that two different pathways of photoreceptor-cell apoptosis are induced by light. Bright light induces apoptosis that is independent of transducin and accompanied by induction of the transcription factor AP-1. By contrast, low light induces an apoptotic pathway that requires transducin. We also provide evidence that additional genetic factors regulate sensitivity to light-induced damage. Our use of defined mouse mutants resolves some of the complexity underlying the mechanisms that regulate susceptibility to retinal degeneration. |
