| First Author | Alam NM | Year | 2015 |
| Journal | Invest Ophthalmol Vis Sci | Volume | 56 |
| Issue | 3 | Pages | 1842-9 |
| PubMed ID | 25670495 | Mgi Jnum | J:230975 |
| Mgi Id | MGI:5766606 | Doi | 10.1167/iovs.14-15644 |
| Citation | Alam NM, et al. (2015) Photoreceptor regulation of spatial visual behavior. Invest Ophthalmol Vis Sci 56(3):1842-9 |
| abstractText | PURPOSE: To better understand how photoreceptors and their circuits support luminance-dependent spatial visual behavior. METHODS: Grating thresholds for optokinetic tracking were measured under defined luminance conditions in mice with genetic alterations of photoreceptor activity. RESULTS: The luminance conditions that enable cone- and rod-mediated behavior, and the luminance range over which rod and cone functions overlap, were characterized. The AII amacrine pathway was found to support low-resolution and high-contrast function, with the rod-cone pathway supporting high-resolution and low-contrast function. Rods alone were also shown to be capable of driving cone-like spatial visual function, but only when cones were genetically maintained in a physiological dark state. CONCLUSIONS: The study defined how luminance signals drive rod- and cone-mediated spatial visual behavior and revealed new and unexpected contributions for rods that depend on an interaction between cone and rod systems. |
