| First Author | Hirai H | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 7 | Pages | 732-9 |
| PubMed ID | 16751774 | Mgi Jnum | J:112664 |
| Mgi Id | MGI:3662983 | Doi | 10.1038/ni1354 |
| Citation | Hirai H, et al. (2006) C/EBPbeta is required for 'emergency' granulopoiesis. Nat Immunol 7(7):732-9 |
| abstractText | During 'emergency' situations such as infections, host defense requires rapid mobilization of bone marrow granulocyte progenitors. 'Steady-state' granulopoiesis is absolutely dependent on the C/EBPalpha transcription factor, but the transcriptional mechanisms underlying emergency granulopoiesis remain unclear. Here we show that large numbers of granulocytes were generated from C/EBPalpha-deficient progenitors after cytokine stimulation in vivo. Cytokine treatment or fungal infection induced upregulation of C/EBPbeta but not C/EBPalpha or C/EBPepsilon transcripts in granulocyte progenitors, and C/EBPbeta-deficient progenitors showed decreased emergency-induced granulopoiesis in vitro and in vivo. C/EBPbeta inhibited proliferation less severely than did C/EBPalpha. These data suggest a critical function for C/EBPbeta in emergency granulopoiesis, which demands both differentiation and proliferation of granulocyte precursors. |
